Kainic Acid-Induced Seizures Enhance Dentate Gyrus Inhibition by Downregulation of GABABReceptors
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چکیده
منابع مشابه
Kainic acid-induced seizures enhance dentate gyrus inhibition by downregulation of GABA(B) receptors.
Seizures cause a persistent enhancement in dentate synaptic inhibition concurrent with, and possibly compensatory for, seizure-induced hippocampal hyperexcitability. To study this phenomenon, we evoked status epilepticus in rats with systemic kainic acid (KA), and 2 weeks later assessed granule cell inhibition with paired-pulse stimulation of the perforant path (PP) in vitro. Controls demonstra...
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Adult neurogenesis occurs in the subventricular zone and the hippocampal dentate gyrus (DG) of the mammalian brain. Research on rodents shows that neurogenesis in the DG increases with seizures (Abrous et al., 2005), a finding that may help reveal the underlying mechanism of temporal lobe epilepsy (TLE). In our experiment, systemic seizures were induced in mice by kainic acid (KA), followed by ...
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ژورنال
عنوان ژورنال: The Journal of Neuroscience
سال: 1996
ISSN: 0270-6474,1529-2401
DOI: 10.1523/jneurosci.16-13-04250.1996